Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system.
نویسندگان
چکیده
A mesoporous silica nanoparticle-based intracellular cysteine delivery system that could be induced and regulated by cell-produced natural antioxidants was synthesized.
منابع مشابه
Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins.
An MCM-41-type mesoporous silica nanoparticle (MSN) material with a large average pore diameter (5.4 nm) is synthesized and characterized. The in vitro uptake and release profiles of cytochrome c by the MSN were investigated. The enzymatic activity of the released protein was quantitatively analyzed and compared with that of the native cytochrome c in physiological buffer solutions. We found th...
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عنوان ژورنال:
- Chemical communications
دوره 22 شماره
صفحات -
تاریخ انتشار 2009